Description

Amyloid beta 1-42 (Aβ42) plays a central role in the pathogenesis of Alzheimer’s disease (AD). Recombinant Aβ42 has reproducibly been shown to have higher in vitro toxicity and aggregate significantly faster than synthetically prepared Aβ42 due to the absence of (n-1) deletion products and racemized amino acids that are characteristic of chemical synthesis (Finder et al J.Mol. Biol.).